What is Slay the Spire 2 Guide?
The ultimate Slay the Spire 2 resource. Browse 567 cards, 286 relics, class guides, tier lists, and the co-op synergy builder. Updated for EA 2026. Damage Calculator Test card lines with Strength, Vulnerable, Block, Poison, etc. to see if a turn is actually lethal before you commit. Co-op Synergy Builder Pick your team’s classes (2–4 players) and see which co-op cards and class combos synergize best, plus how your team scales as you add more players.
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